A STUDY ON THE NOSE TO BRAIN DRUG DELIVERY SYSTEM

Mrugendra Bhojraj Potdar, Dr. Neetesh Kumar Jain

Abstract


Drugs has controlled by the nasal route for remedial and therapeutic use since ancient times. Enthusiasm and importance for the basic impacts of drugs directed via the nasal route have developed to last decades. Intra-nasal drug organization provides a attractive substitute for achieve the important beneficial impacts of drugs which is virtually similar to the parenteral route, that may be improperly engineered on occasion or through oral organization, that may contribute to inadequately low bioavailability of drugs. It is crucial, along these lines, to identify with the potential and impediments of various nasal drug conveyance frameworks. In this way, the object of this paper to study the different forms of pharmaceutical dosage that may be utilized in the vicinity or in a basic drug organization. It is obviously anticipated that this study would help to understand and advance expand appropriate intra-nasal strategies to meet specific restorative goals.


Keywords


Nose, Intra-Nasal, Bioavailability, Biopharmaceutical, Mucoadhesion, Drug Delivery Systems

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References


BHATT, R., SINGH, D., PRAKASH, A., MISHRA, N. (2015) Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington's disease. Drug Delivery. 22(7), 931-939.

CASETTARI, L., and ILLUM, L. (2014). Chitosan in nasal delivery systems for therapeutic drugs. Journal of Controlled Release, 190, 189-200.

CHATURVEDI, M., KUMAR. M., and PATHAK. K., (2011). A review on mucoadhesive polymer used in nasal drug delivery system. Journal of Advanced Pharmaceutical Technology and Research

Fernandes C, Soni U, Patravale V. 2010. Nano-interventions for neurodegenerative disorders. Pharmacological Research, 62: 166-178.

GALGATTE, U. C., KUMBHAR, A. B., and CHAUDHARI, P. D. (2014). Development of in situ gel for nasal delivery: design, optimization, in vitro and in vivo evaluation. Drug Delivery, 21(1), 62-73.

GAVINI, E., RASSU, G., FERRARO, L., GENEROSI, A., RAU, J. V., BRUNETTI, A., and DALPIAZ, A. (2011). Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres. Journal of Pharmaceutical Sciences, 100(4), 1488-1502.

Ghori MU, Mahdi MH, Smith AM, Conway BR. 2015. Nasal Drug Delivery Systems: An Overview. American Journal of Pharmacological Sciences, 3(5): 110-119.

HUSSEIN, N. R., (2014). Bioadhesive microparticles and liposomes of anti-Parkinson drugs for nasal delivery. PhD thesis, University of Central Lancashire.

J.J. Lochhead, R.G. Thorne, Intranasal delivery of biologics to the central nervous system, Adv. Drug Deliv. Rev. 64 (2012) 614–628.

KLANG, V., SCHWARZ, J. C., and VALENTA, C. (2015). Nanoemulsions in Dermal Drug Delivery. In Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement (pp. 255-266). Springer Berlin Heidelberg.

MAHDI, M. H., CONWAY, B. R., and SMITH, A. M. (2015). Development of mucoadhesive sprayable gellan gum fluid gels. International Journal of Pharmaceutics, 488(1), 12-19. MENAKA, M., and PANDEY, V. P. Formulation development and evaluation of cinnarizine nasal spray. Pharma Health Sciences, 2(4), 339-346.

OTTO, D. P., OTTO, A., and DE VILLIERS, M. M. (2015). Differences in physicochemical properties to consider in the design, evaluation and choice between microparticles and nanoparticles for drug delivery. Expert Opinion in Drug Delivery.

S. Sood, K. Jain, K. Gowthamarajan, Intranasal therapeutic strategies for management of Alzheimer's disease, J. Drug Target. 22 (2014) 279–294.

SCALIA, S., YOUNG, P. M., and TRAINI, D. (2015). Solid lipid microparticles as an approach to drug delivery. Expert Opinion on Drug Delivery, 12(4)

SHINDE, R. L., BHARKAD, G. P., and DEVARAJAN, P. V. (2015). Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: role of docosahexaenoic acid. European Journal of Pharmaceutics and Biopharmaceutics, 96, 363-379.

ZHANG, X., and WU, B. (2015). Submicron lipid emulsions: a versatile platform for drug delivery. Current Drug Metabolism, 16(3), 211-220.


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