Formulation and Development of Topical Dosage Form of Ibuprofen Using Mixed Solvency Concept and its Evaluations

Nagwanshi, K, Maheshwari, R.K, Padiyar, A


Solubilization of poorly water-soluble drug is encountered on challenging factor and has been a really vital issue in screening studies of new chemical entities as well as formulation research. Thus, leading to difficulties in several developmental, manufacturing and administrative processes. Furthermore, the clinical trials of these drugs have witnessed a great failure due to their poor pharmacokinetics. The lineup of our research work was promotion of mixed solvency concept by formulating the topical solution and topical gel of poorly water-soluble drug ibuprofen by decreasing the solubilisers concentration in small proportion for expected synergistic enhancement of drug solubility in water. For poorly water soluble drug ibuprofen, solubilizers such as sodium acetate, sodium caprylate, sodium citrate, propylene glycol and urea has been used in combinations as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility of drug and thereby resulting in expected enhanced permeation of ibuprofen from its topical formulations. The procured sample of ibuprofen was characterized by melting point, UV and DSC studies. The formulations were evaluated for various properties of solution and gels such as pH, freeze thaw study and thin layer chromatography, physical appearance. Mixed solvency concept was successfully employed to improve the solubility and permeation of poorly water soluble drug, ibuprofen


Solubility, Ibuprofen, solution, gel

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