Evaluation of Phytochemical, Antioxidant, Anti-inflammatory Antimicrobial, Anti-Cancerous and Wound Healing Potential of Syzygium zeylanicum

Abstract

The study was carried out to analyse the phytochemical, anti-oxidant, anti-inflammatory, anti-microbial, anti-cancerous and wound healing potential of the leaves of Syzygium zeylanicum (S. zeylanicum). The phytochemical screening showed the presence of alkaloids, flavonoids, tannins, saponins and phytosterols in the methanolic extract of S. zeylanicum leaves. The antioxidant activity of methanolic leaf extract of S. zeylanicum showed an increase with concentration. The higher concentration (100%) showed the maximum rate of absorbance as 3.00nm and the lowest concentration (50%) with an absorbance of 2.19nm. The anti-inflammatory potential of S. zeylanicum (methanolic leaf extract) showed rate of inhibition ranging from 3.7% to 106.7% for concentrations (800 to 1200μg/ml) respectively. The antimicrobial assay of methanolic leaf extract of S. zeylanicum showed zone of inhibition (ZOI) around 21.5mm (100%) against Klebsiella pneumoniae (K. pneumoniae) but there was no ZOI against Aspergillus niger (A. niger). MTT assay showed highest cell viability percentage for the concs. 1:250 and 1:125. Leaf extract of S. zeylanicum at 1:125 and 1:250 had the highest wound closure rate when compared to other concs.